Catalyst-Free Dehydrative α-Alkylation of Ketones with Alcohols: Green and Selective Autocatalyzed Synthesis of Alcohols and Ketones†
Keywords:
- alcohols;
- aldehydes;
- autocatalysis;
- reduction;
- synthetic methods
Abstract
Direct dehydrative α-alkylation reactions of ketones with alcohols are now realized under simple, practical, and green conditions without using external catalysts. These catalyst-free autocatalyzed alkylation methods can efficiently afford useful alkylated ketone or alcohol products in a one-pot manner and on a large scale by C![[DOUBLE BOND]](/__local/9/64/6F/26246CDA0D1D07DF738A6FE6C14_46444019_69.gif?e=.gif)
C bond formation of the in situ generated intermediates with subsequent controllable and selective Meerwein–Pondorf–Verley–Oppenauer-type redox processes.
原文链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201308642/abstract
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