个人简介

张兴国，博士，教授，韩国全南大学联合博士生导师。1998年毕业于江西师范大学化学系，同年保送本校有机化学硕士研究生。1999至2001年联合培养在中国科学院上海有机化学研究所元素有机室完成了硕士论文。2001年7月于温州师范学院参加工作。2004年9月考入东华大学，2008年6月获得工学博士学位。2011年-2012年访学美国Scripps研究所。近年来主持国家自然科学基金，浙江省自然科学基金多项。2015年获浙江省自然科学基金委杰出青年基金。2007年获浙江省高校优秀青年教师资助计划，2011获浙江省新世纪151人才工程第三层次。2017年获浙江省高等学校中青年学科带头人。近年来从事金属有机化学和有机氟化学研究，发表论文60余篇。

代表论著

近年来发表文章如下：

(59). Zhang, X.-G.; Dai, H,-X.; Wasa, M.; Yu, J.-Q.*, Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups, J. Am. Chem. Soc., 2012, 134, 11948-11951.

(58). Guo, Y.-Q.; Chen, F.*; Deng, C.-L.; Zhang, X.-G.*, Iodine-promoted ring-opening methylation of benzothiazoles with dimethyl sulfite, Chem. Comm., 2021, 57, 1923-1926.

(57). Shen, X.-Q.; Wang, S.-Q.; Fan, D.; Zhang, X.-G.*; Tu, H.-Y.*; Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides, J. Org. Chem. 2021, 86, 1591-1600.

(56). Zhang, Z.-Z.; Chen, R.; Zhang, X.-H.*; Zhang, X.-G.*, Synthesis of Isoselenazoles and Isothiazoles from Demethoxylative Cycloaddition of Alkynyl Oxime Ethers, J. Org. Chem. 2021, 86, 632-642.

(55). He, S.-Y.; Zhang, X.-G.*, Palladium-catalyzed selective defluorinative sulfenylation for the synthesis of fluorovinylthioethers, Org. Chem. Front., 2020, 7, 3174-3178.

(54). Hu, B.-L.; Song, Y.-K.; Zhang, G.; Yao, Z. Zhang, X.-G.*, Copper-catalyzed three component C–S/C–N coupling for the synthesis of trifluorothioacetamides, J. Fluorine Chem. 2020, 239, 109640.

(53). Wang, S.-Q.; Yan, X.-W.*; Hu, B.-L.; Zhang, X.-G.*, Transition-metal and base-free thioannulation of propynamides with sodium sulfide and dichloromethane for the selective synthesis of 1,3-thiazin-4-ones and thiazolidine-4-ones, Tetrahedron, 2020, 76, 131021.

(52). Li, L.; Chen, Q.; Xu, H.-H.; Zhang, X.-H.*; Zhang, X.-G.*, DBU-Promoted Demethoxylative Thioannulation of Alkynyl Oxime Ethers with Sulfur for the Synthesis of Bisisothiazole-4-yl Disulfides, J. Org. Chem. 2020, 85, 10083-10090.

(51). Xu, H.-H.; Zhang, X.-H.*; Zhang, X.-G.*, Thioamidation of Arylpropyne Derivatives with Sulfur and Formamides for the Synthesis of Aryl Propanethioamides, Asian J. Org. Chem. 2020, 9, 111-115.

(50). Xu, H.-H.; Zhang, X.-H.*; Zhang, X.-G.*, Copper-Catalyzed Tandem Sulfuration/Annulation of Propargylamines with Sulfur via C−N Bond Cleavage, J. Org. Chem. 2019, 84, 7894-7900.

(49). He, S.-Y.; Xiong, J.*; Hu, B.-L.; Zhang, X.-G.*, Copper-catalyzed tandem cyclization and vinylation for the synthesis of 2-trifluoromethyl benzofurans, J. Fluorine Chem. 2019, 228, 109418.

(48). Li, L.; Zhang, X.-G.*; Hu, B.-L.; Zhang, X.-H.*, Copper-Catalyzed Electrophilic Cyclization of N-Propargylamines with Sodium Sulfinate for the Synthesis of 3-Sulfonated Quinolines, Chem. Asian J. 2019, 14, 4358-4364.

(47). Zhou, X.-C.; Hei, Y.-Y.; Song, J.-L.; Qian, P.-C.; Zhang, X.-G.*; Deng, C.-L.*, Copper-catalyzed direct C–H phosphorylationof N-imino isoquinolinium ylides with H-phosphonates, Org. Chem. Front., 2019, 6, 1453-1457.

(46). Zhou, M.; Zhang, J.; Zhang, X.-G.*; Zhang, X.*, Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition Reaction, Org. Lett. 2019, 21, 671-674.

(45). Wang, S.-Q.; Hu, B.-L.; Zhang, X.-G.*, Copper-Catalyzed Thioannulation of Propynamides with Sodium Sulfide for the Synthesis of Isothiazol-3-ones, Adv. Synth. Catal. 2019, 361, 1459-1462.

(44). Wei, F.; Zhang, X.-G.*, Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur, Chem. Comm., 2019, 55, 1144-1147.

(43). Zhang, T.; Chen, F.*; Zhang, X.-H.; Qian, P.-C.; Zhang, X.-G.*, , Palladium-Catalyzed Tandem Carbocyclization and Hetroarylation for the Synthesis of 2-(Trifluoromethyl)indenylmethyleneindoles, J. Org. Chem., 2019, 84, 307-313.

(42). Wei, F.; Shen, X.-Q.; Zhang, X.-H.; Zhang, X.-G.*, Copper-Catalyzed Defluorinative Thioannulation of Trifluoropropynes for the Synthesis of 1,2-Dithiole-3-thiones, Adv. Synth. Catal. 2018, 360, 3911-3915.

(41). Li, X.-F.; Zhang, X.-G.*, Chen, F.; Zhang, X.-H.*, Copper-Catalyzed N- Formylation of Amines through Tandem Amination/Hydrolysis/Decarboxylation Reaction of Ethyl Bromodifluoroacetate, J. Org. Chem., 2018, 83, 12815-12821.

(40). Li, X.-F.; Shi, L.-F.; Zhang, X.-G.*; Zhang, X.-H.*, Pd-Catalyzed C(sp2)–H aminocarbonylation using the Langlois reagent as a carbonyl source, Org. Biomol. Chem., 2018, 16, 6438-6442.

(39). Li, X.-F.; Zhang, X.-G.*, Hu, B.-L.; Zhang, X.-H.*, Palladium-catalyzed dimerization of N-aryl propargylamines for the synthesis of 3-vinylquinolines, Org. Biomol. Chem., 2018, 16, 1736-1744.

(38). Zhou, M.; Wang, F.; Zhang, X.-H.*; Tu, H.-Y.; Zhang, X.-G.*, Photoredox-catalyzed chloroalkylation and dimerization of styrenes with CF3CCl3 and CCl4, J. Fluorine Chem., 2018, 215, 10-16.

(37). Wei, F.; Shen, X.-Q.; Chu, J.-J.; Hu, B.-L.; Zhang, X.-G.*, Palladium-catalyzed intramolecular aerobic C-H amination of enamines for the synthesis of 2-trifluoromethylindoles, Tetrahedron, 2018, 74, 720-725.

(36). Wang, F.; Zhang, T.; Tu, H.-Y.; Zhang, X.-G.*, Transition-Metal-Free Conversion of Trifluoropropanamides into Cyanoformamides through C-CF3 Bond Cleavage and Nitrogenation, J. Org. Chem., 2017, 82, 5475-5480.

(35). Wang, F.; Hu, B.-L.; Liu, L.; Tu, H.-Y.; Zhang, X.-G.*, One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N-Aryl Cyanoacetamides, J. Org. Chem., 2017, 82, 11247-11252.

(34). Liu, Y.; Hu, B.; Zhang, X.-G.*, Copper Catalyzed Iodosulfenylation of Styrenes by Dual C-H Oxidative Functionalization, Chin. J. Chem., 2017, 35, 307-310.

(33). Lin, Y.-F.; Wang, C; Hu, B.-L.; Qian, P.-C.; Zhang, X.-G.*, Iron-Catalyzed Thiocyclization for the Synthesis of Trifluoromethylated Benzothiophenes by C-H Functionalization of Aryl Disulfides, Synlett, 2017, 28, 707-712.

(32). Zhang, X.-S.; Jiao, J.-Y.; Zhang, X.-H.*; Hu, B.-L.; Zhang, X.-G.*, Synthesis of 2-Sulfenylindenones via One-Pot Tandem Meyer-Schuster Rearrangement and Radical Cyclization of Arylpropynols with Disulfides, J. Org. Chem., 2016, 81, 5710-5716.

(31). Chu, J.-J.; Hu, B.-L.; Liao, Z.-Y.; Zhang, X.-G.*, Copper-Catalyzed Three-Component Tandem Cyclization for One-Pot Synthesis of 1,4-Benzothiazine, J. Org. Chem., 2016, 81, 8647-8652.

(30). Song, Y.-K.; Qian, P.-C.; Chen, F.*; Deng, C.-L.; Zhang, X.-G.*, Synthesis of 2-(trifluoromethylthio)-indenones by silver-mediated cascade trifluoromethylthiolation/cyclization of arylpropynones, Tetrahedron, 2016, 72, 7589-7593.

(29). Tu, H.-Y.; Hu, B.-L.; Deng, C.-L.; Zhang, X.-G.*, Copper-mediated stereospecific C–H oxidative sulfenylation of terminal alkenes with disulfides, Chem. Comm., 2015, 51, 15558-15561.

(28). Liu, Y.; Tu, H.-Y.; Zhang, X.-G.*, Silver-Catalyzed Tandem Trifluoromethylation and Cyclization of Aryl Isonitriles with the Langlois Reagent, Synthesis, 2015, 47, 3460-3466.

(27). Yao, B.; Deng, C.-L.; Liu, Y.; Tang R.-Y.; Zhang, X.-G.*; Li, J.-H.*, Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C–H oxidative coupling, Chem. Comm., 2015, 51, 4097-4100.

(26). Qiu, J.-W.; Hu, B.-L.; Zhang, X.-G.*; Tang R.-Y.; Zhong, P.; Li, J.-H.*, Copper-catalyzed ring expansion of 2-aminobenzothiazoles with alkynyl carboxylic acids to1,4-benzothiazines, Org. Biomol. Chem., 2015, 13, 3122-3127.

(25) Zhang, X.-S.; Li, G.-X.; Zhang, X.-G.*; Zhang, X.-H. *, Pd(II)-catalyzed selective sulfenylation of arene C-H bonds using N-arylthiobenzamides as thiolation reagent and oxidant, Tetrahedron, 2015, 71, 5458-5464.

(24). Yang, Z.-J.; Liu, C.-Z.; Hu, B.-L.; Deng, C.-L.; Zhang, X.-G.*, Oxidative tandem nitrosation/ cyclization of N-aryl enamines with nitromethane toward 3-(trifluoromethyl)quinoxaline, Chem. Comm., 2014, 50, 14554-14557.

(23). Tu, H.-Y.; Liu, Y.-L.; Chu, J.-J.; Hu, B.-L.; Zhang, X.-G.*, FeCl3 Promoted Carboxamidation and Cyclization of Aryl Isonitriles with Formamides toward Phenanthridine-6-carboxamides, J. Org. Chem., 2014, 79, 9907-9912.

(22). Yang, Z.-J.; Hu, B.-L.; Deng, C.-L.; Zhang, X.-G.*, Iron-Promoted Electrophilic Annulation of Aryl Enynes with Disulfides or Diselenides Leading to Polysubstituted Naphthalenes, Adv. Synth. Catal. 2014, 356, 1962-1966.

(21). Wang, W.-Y.; Hu, B.-L.; Deng, C.-L.; Zhang, X.-G.*, One-pot Synthesis of 3-Trifluoromethyl -benzofurans via Tandem Iodocyclization and Trifluoromethylation of 2-Alkynylanisoles, Tetrahedron Lett., 2014, 55, 1501-1503.

(20). Wang, C.; Chen, L.-H. *; Deng, C.-L.; Zhang, X.-G.*, Synthesis of 3 Trifluoromethylbenofurans via Palladium-Catalyzed Tandem Elimination/ Annulation of β-Chloro-β-(trifluoromethyl)styrenes with 2-Halophenols, Synthesis, 2014, 46, 313-319. Highlighted by Synfacts, 2014, 10, 132.

(19). Wang, W.-Y.; Feng, X.; Hu, B.-L.; Deng, C.-L.; Zhang, X.-G.*, Synthesis of 6 (Trifluoromethyl)phenanthridines via Palladium-Catalyzed Tandem Suzuki/C−H Arylation Reactions, J. Org. Chem., 2013, 78, 6025-6030.

(18). Hu, B.-L.; Li, C.-L.; Liao, Z.-Y.; Zhang, X.-G.*, Tetrabutylammonium Bromide Catalyzed Tandem Addition/Cyclization of o-Aralkynylaryl Aldehydes with Trimethyl(trifluoromethyl) -silane: Synthesis of Trifluoromethyl Group Containing Phthalans, Synlett, 2013, 24, 2748-2750.

(17). Dai, H.-X.; Li, G.; Zhang, X.-G., Stepan, A. F.; Yu, J.-Q.*, Pd(II)-Catalyzed ortho- or meta- C−H Olefination of Phenol Derivatives, J. Am. Chem. Soc., 2013, 135, 7567-7571.

(16). Hu, B.-L.; Pi, S.-S.; Qian, P.-C.*; Li, J.-H.; Zhang, X.-G.*, Palladium-Catalyzed Iodine-Mediated Electrophilic Annulation of 2-(1-Alkynyl)biphenyls with Disulfides, J. Org. Chem., 2013, 78, 1300-1305.

(15). Sun, L.-L.; Hu, B.-L.; Tang, R.-Y.; Deng, C.-L.; Zhang, X.-G.*, Copper-Catalyzed Tandem C-C/C-O Bond-Forming Reactions of ortho-Halo-β-chlorostyrenes with Ketones: Synthesis of 4-Trifluoromethyl- benzoxepines, Adv. Synth. Catal. 2013, 355, 377–382.

(14). Wang, W.-Y.; Sun, L.-L.; Deng, C.-L.; Tang, R.-Y.; Zhang, X.-G.*, Palladium Catalyzed Tandem Carbocyclization/Suzuki Coupling Reaction of Trifluoromethyl-Containing Building Blocks Leading to 2-Trifluoromethylindenes, Synthesis, 2013, 45, 118-126.

(13). Wasa, M.; Chan, K. S. L.; Zhang, X.-G., He, J.; Miura, M.; Yu, J.-Q.*, Ligand-Enabled Methylene C(sp3)−H Bond Activation with a Pd(II) Catalyst, J. Am. Chem. Soc., 2012, 134, 18570-18572.

(12). Sun, L.-L.; Liao, Z.-Y.; Tang, R.-Y.; Deng, C.-L.; Zhang, X.-G.*, Palladium and Copper Co-catalyzed Tandem N-H/C-H Bond Functionalization: Synthesis of CF3-Containing Indolo- and Pyrrolo[2,1-a]isoquinolines, J. Org. Chem., 2012, 77, 2850-2856.

(11). Shi, S.; Sun, L.-L.; Liao, Z.-Y.; Zhang, X.-G.*, Copper-Catalyzed Thiolation Cyclization of 1-Chloro-1,5-enynes with Sodium Hydrosulfide: Synthesis of CF3-Containing 1H-Isothiochromenes, Synthesis, 2012, 44, 966-972.

(10). Sun, L.-L.; Deng, C.-L.; Tang, R.-Y.; Zhang, X.-G.*, CuI/TMEDA-Catalyzed Annulation of 2-Bromo Alkynylbenzenes with Na2S: Synthesis of Benzo[b]thiophenes, J. Org. Chem. 2011, 76, 7546–7550. Highlighted by Synfacts, 2011, 12, 1295.

(9). Du, H.-A.; Tang, R.-Y.; Deng, C.-L.; Liu, Y.; Li, J.-H.*; Zhang, X.-G.*, Iron-Facilitated Iodine-Mediated Electrophilic Annulation of N,N-Dimethyl-2-alkynylanilines with Disulfides or Diselenides, Adv. Synth.Catal. 2011, 353, 2739–2748.

(8). Fang, X.-L.; Tang, R.-Y.; Zhang, X.-G.*; Li, J.-H.*, FeF3/I2-Catalyzed Synthesis of 4-Chalcogen-Substituted Arylamines by Direct Thiolation of an Arene C–H Bond, Synthesis, 2011, 1099-1105.

(7). Li, C.-L. Zhang, X.-G.*; Tang, R.-Y.; Zhong, P.; Li, J.-H.*, Copper-Catalyzed Thiolation Annulations of 1,4-Dihalides with Sulfides Leading to 2-Trifluoromethyl Benzothiophenes and Benzothiazoles, J. Org. Chem. 2010, 75, 7037–7040.

(6). Dong, S.-X.; Zhang, X.-G.*; Liu, Q.; Tang, R.-Y.; Zhong, P.; Li, J.-H.*, Synthesis of 1-Substituted 2-(Trifluoromethyl)indoles via a Palladium-Catalyzed Double Amination Reaction, Synthesis, 2010, 1521-1525.

(5). Li, C.-L.; Chen, M.-W.; Zhang, X.-G.*, Synthesis of N-aryl Trifluoromethylaryl-Ketoimines by Palladium-Catalyzed Suzuki Coupling Reaction of N-Aryltrifluoroacetimidoyl Chlorides with Arylboronic Acids, J. Fluorine Chem. 2010, 131, 856–860.

(4). Guo, Y.-J.; Tang, R.-Y.; Li, J.-H.*; Zhong, P.; Zhang, X.-G.*, Palladium-Catalyzed Annulation of 2-(1-Alkynyl)benzenamines with Disulfides: Synthesis of 3-Sulfenylindoles, Adv. Synth. & Catal. 2009, 351, 2615-2618.(3). Du, H.-A.; Zhang, X.-G.*; Tang, R.-Y.; Li, J.-H.*, PdCl2-Promoted Electrophilic Annulation of 2-Alkynylphenol Derivatives with Disulfides or Diselenides in the Presence of Iodine, J. Org. Chem. 2009, 74, 7844-7848.

(2). Chen, M.-W.; Zhang, X.-G.*; Zhong, P.; Hu, M.-L., Copper-Catalyzed Tandem C-N Bond Formation Reaction: Selective Synthesis of 2-(Trifluoromethyl)benzimidazoles, Synthesis, 2009, 1431-1436.

(1). Zhang, X.-G.*; Chen, M.-W.; Zhong, P.*; Hu, M.-L., Regio- and Stereo-specific Preparation of (E)-1-Aryl-3,3,3-trifluoro-1-iodo-propenes and Their Palladium-Catalyzed Reaction with Terminal Alkynes, J. Fluorine Chem. 2008, 129, 335-342.

主要项目

1.钯催化环化反应合成含硫杂环化合物的研究，浙江省自然科学基金，项目批准号(Y4100307)，起止年月2010-2012.

2.钯催化多组分环化反应合成含硫杂环化合物的研究，国家自然科学基金，项目批准号(21002070)，起止年月2011-2013.

3.钯催化C-H官能团化合成三氟甲基化合物的研究，国家自然科学基金，项目批准号(21272177)，起止年月2013-2016.

4.基于稠杂芳烃构建的氟化、硫化反应及应用研究, 浙江省杰出青年基金，项目批准号(R15B020006)，起止年月2015-2018.