Qing XU, Ph.D. Professor of Chemistry Organic Chemistry, Green Chemistry   E-mail: qing-xu@wzu.edu.cn Phone: +86-13857745327 Address: Room 11B-401, College of Chemistry and Materials Engineering, Wenzhou University (South Campus), Chashan University Town , Wenzhou , Zhejiang 325035, China Web site: /Art/Art_120/Art_120_5190.aspx

 

Education

1999.09-2004.06  Ph.D., Organic Chemistry (Supervisor: Prof. Xian Huang), Zhejiang University , Zhejiang , China

1995.09-1999.06  B.S., Chemistry (Supervisor: Prof. Xian Huang), Zhejiang University , Zhejiang , China

Research Experience

2015.03-2015.09  Visiting Professor (with Prof. Shannon Stahl), University of Wisconsin-Madison , Madison , Wisconsin , USA

2012.12-present   Professor, Wenzhou University , Zhejiang , China

2009.04-2012.11   Lecturer/Associate Professor, Wenzhou University , Zhejiang , China

2004.10-2009.03   Special Scientist (Postdoc, with Prof. Li-Biao Han), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba , Japan

Research Interests

Green synthetic methodologies, catalytic aerobic oxidative reactions, organoelemental chemistry, organometallic chemistry, and mechanistic studies of new reactions.

Awards and Honors

Zhejiang Natural Science Foundation for Distinguished Young Scholars, Zhejiang , China , 2014.

580 Program for Distinguished Overseas Scholars, Wenzhou , China , 2013.

Selected Publications

1.        Jianhui Chen,† Yang Li,† Shuangyan Li, Jianping Liu,* Fei Zheng, Zhengping Zhang, and Qing Xu* († These authors contribute equally to this work), Aldehyde/Ketone-Catalyzed Highly Selective Synthesis of 9-Monoalkylated Fluorenes by Dehydrative C-Alkylation with Primary and Secondary Alcohols, Green Chem. 2016, DOI: 10.1039/c6gc02518h.

2.        Xiang Ren, Qihang Guo, Jianhui Chen, Hujun Xie,* Qing Xu* and Zhan Lu*. Visible-Light Promoted Distereodivergent Intramolecular Oxyamidation of Alkenes. Chem. Eur. J. 2016, DOI: 10.1002/chem.201603977.

3.        Xiaokai Cheng, Bo Yang, Xingen Hu, Qing Xu, and Zhan Lu,* Visible-Light-Promoted Metal-Free Aerobic Oxidation of Primary Amines to Acids and Lactones. Chem. Eur. J. 2016, DOI: 10.1002/chem.201604440.

4.        Yang Li,† Haonan Chen,† Jianping Liu,* Xujun Wan, and Qing Xu* († These authors contribute equally to this work), Clean Synthesis of Primary to Tertiary Carboxamides by CsOH-Catalyzed Aminolysis of Nitriles in Water, Green Chem. 2016, 18, 4865–4870. (DOI: 10.1039/C6GC01565D)

5.        Wang, Wei-Min; Liu, Li-Juan; Yao, Lan; Meng, Fan-Jie; Sun, Yong-Ming; Zhao, Chang-Qiu; Xu, Qing; Han, Li-Biao. Stereospecific Preparations of P-Stereogenic Phosphonothioates and Phosphonoselenoates. J. Org. Chem. 2016, 81 (15), 6843-6847 (DOI: 10.1021/acs.joc.6b01192)

6.        Jianping Liu,* Chao Wang, Xiantao Ma, Xinkang Shi, Xin Wang, Huan Li, and Qing Xu.* Simple Synthesis of Benzazoles by Substrate-Promoted CuI-Catalyzed Aerobic Oxidative Cyclocondensation of o-Thio/Amino/Hydroxyanilines and Amines under Air. Catal. Lett. 2016, 146 (10), 2139-2148. (DOI: 10.1007/s10562-016-1818-2)

7.        Qing Xu,* Huamei Xie, Er-Lei Zhang, Xiantao Ma, Jianhui Chen, Xiao-Chun Yu, and Huan Li. Selective Catalytic Hoffmann N-Alkylation of Poor Nucleophilic Amines and Amides with Catalytic Amounts of Alkyl Halides. Green. Chem. 2016, 18 (14), 3940-3944. (DOI: 10.1039/C6GC00938G)

8.        Xiantao Ma, Quan Liu, Xiaojuan Jia, Chenliang Su* and Qing Xu*, Efficient Synthesis of Unsymmetrical Heteroaryl Thioethers and Chalcogenides by Alkali Hydroxide-Mediated S_NAr Reactions of Heteroaryl Halides and Dichalcogenides, RSC Adv. 2016, 6 (62), 56930-56935 (DOI: 10.1039/C6RA10517C).

9.        Xiantao Ma, Chenliang Su, Qing Xu*, Chapter 7: N-Alkylation by hydrogen autotransfer reactions (Invited Review) in Hydorgen Transfer Reactions (Eds. Guillena, G.; Ramón, D. J.), Top. Curr. Chem. 2016, 374, 27 (DOI: 10.1007/s41061-016-0027-1).

10.   Qiang Li, Tieqiao Chen, Qing Xu,* Li-Biao Han.* Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active α-Hydroxyphosphinates. Chem. Eur. J. 2016, 22 (18), 6213-6217 (DOI：dx.doi.org/10.1002/chem.201600115). Highlighted by Synfacts: Synfacts 2016, 12(7), 0710

11.   Xiaohui Li, Shuangyan Li, Qiang Li, Xu Dong, Yang Li, Xiaochun Yu, Qing Xu.* Efficient and Practical Catalyst-Free-Like Dehydrative N-Alkylation of Amines and Sulfinamides with Alcohols Initiated by Aerobic Oxidation of Alcohols under Air. Tetrahedron 2016, 72 (2), 264-272 (DOI: 10.1016/j.tet.2015.11.016).

12.   Lei Yu,* Yaping Huang, Zheng Wei, Yuanhua Ding, Chenliang Su,* Qing Xu.* Heck Reactions Catalyzed by Ultrasmall and Uniform Pd Nanoparticles Supported on Polyaniline. J. Org. Chem. 2015, 80 (17), 8677–8683 (DOI: 10.1021/acs.joc.5b01358; Highlighted by X-mol: http://www.x-mol.com/news/1350).

13.   Lei Yu,* Jianqing Ye, Xu Zhang, Yuanhua Ding, Qing Xu.* Recyclable (PhSe)2-catalyzed selective oxidation of isatin by H2O2: a practical and waste-free access to isatoic anhydride under mild and neutral conditions. Catal. Sci. Technol. 2015, 5 (10), 4830-4838 (DOI: 10.1039/C5CY01030F).

14.   Lei Yu,* Mingxuan Liu, Fenglin Chen and Qing Xu.* Heterocycles from Methylenecyclopropanes, Org. Biomol. Chem. 2015, 13, 8379-8392 (DOI: 10.1039/C5OB00868A, Front Cover paper).

15.   Xinkang Shi, Junmei Guo, Jianping Liu, Mingde Ye, Qing Xu.^* Unexpectedly Simple Synthesis of Benzazoles by t-BuONa-Catalyzed Direct Aerobic Oxidative Cyclocondensation of o-Thio/Hydroxy/Aminoanilines with Alcohols under Air. Chem. Eur. J. 2015, 21 (28), 9988-9993 (DOI: 10.1002/chem.201501184; Highlighted by Synfacts: Synfacts 2015, 11(9), 0925；Highlighted by Advances in Engineering as a Key Scientific Article contributing to excellence in engineering, scientific and industrial research).

16.   Qing Xu,* Huamei Xie,† Pingliang Chen,† Lei Yu, Jianhui Chen, Xingen Hu* († These authors contribute equally to this work). Organohalides-Catalyzed Dehydrative O-Alkylation between Alcohols: A Facile Etherification Method for Aliphatic Ether Synthesis. Green Chem. 2015, 17 (5), 2774-2779 (DOI:10.1039/C5GC00284B; Highlighted by X-mol: http://www.x-mol.com/news/1171).

17.   Shuangyan Li, Xiaohui Li, Qiang Li, Qiaochao Yuan, Xinkang Shi, Qing Xu.* Structure-Dependent Tautomerization Induced Catalyst-Free Autocatalyzed N-Alkylation of Heteroaryl Amines with Alcohols. Green Chem. 2015, 17 (6), 3260-3265 (DOI:10.1039/C4GC02542C).

18.   Xu Zhang, Jianqing Ye, Lei Yu,* Xinkang Shi, Ming Zhang, Qing Xu,* Mark Lautens. Organoselenium-Catalyzed Baeyer-Villiger Oxidation of α,β-Unsaturated Ketones by Hydrogen Peroxide to Access Vinyl Esters. Adv. Synth. Catal. 2015, 357 (5), 955-960 (DOI:10.1002/adsc.201400957; Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2016/14March.shtm).

19.   Qiang Li, Yao Huang, Tieqiao Chen, Yongbo Zhou,* Qing Xu, Shuang-Feng Yin,* Li-Biao Han. Copper-Catalyzed Aerobic Oxidative Amination of sp³C–H Bonds: Efficient Synthesis of 2-Hetarylquinazolin-4(3H)-ones. Org. Lett. 2014, 16 (14), 3672–3675 (DOI:10.1021/ol501454j).

20.   Lei Yu,* Jun Wang, Hongen Cao, Kehong Ding, Qing Xu*, A Review on Catalyzed Dimerization of Acrylonitrile, Chin. J. Org. Chem. 2014, 37 (7), 1986-1991 (DOI:10.6023/cjoc201405004).

21.   Xiaojuan Jia, Lei Yu, Jianping Liu, Qing Xu,* Marcel Sickert, Lianhui Chen, and Mark Lautens.* Sulfur-silicon bond activation catalysed by Cl/Br ions: waste-free synthesis of unsymmetrical thioethers by replacing fluoride catalysis and fluorinated substrates in S_NAr reactions, Green Chem. 2014, 16 (7), 3444-3449 (DOI:10.1039/C4GC00535J).

22.   Lei Yu,* Jun Wang, Xu Zhang, Hongen Cao, Genling Wang, Kehong Ding, Qing Xu*, Mark Lautens. Practical preparation of 2-methyleneglutaronitrile via an efficient and highly selective head-to-tail dimerization of acrylonitrile catalyzed by low-loading tricyclohexylphosphine. RSC Adv. 2014, 4 (37), 19122-19126 (DOI:10.1039/C4RA02810D).

23.   Haonan Chen, Wujie Dai, Yi Chen, Qing Xu,* Jianhui Chen, Lei Yu, Yajuan Zhao, Mingde Ye, Yuanjiang Pan.* Efficient and selective nitrile hydration reaction in water catalyzed by unexpected dimethylsulfinyl anion generated in situ from CsOH and DMSO. Green Chem. 2014, 16 (4), 2136-2141 (DOI:10.1039/C3GC42310G).

24.   Lei Yu,* Hongyan Li, Xu Zhang, Jianqing Ye, Jianping Liu, Qing Xu,* Mark Lautens. Organoselenium-Catalyzed Mild Dehydration of Aldoximes: An Unexpected Practical Method for Organonitrile Synthesis. Org. Lett. 2014, 15 (3), 1346-1349 (DOI:10.1021/ol500075h; Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/abstracts/lit4/413.shtm).

25.   Qing Xu,* Jianhui Chen, Haiwen Tian, Xueqin Yuan, Shuangyan Li, Chongkuan Zhou, Jianping Liu. Catalyst-Free Dehydrative α-Alkylation of Ketones with Alcohols: Green and Selective Autocatalyzed Synthesis of Alcohols and Ketones. Angew. Chem. 2014, 126 (1), 229-233 (DOI:10.1002/ange.201308642); Angew. Chem. Int. Ed. 2014, 53 (1), 225-229 (DOI:10.1002/anie.201308642; Highlighted by ZJNFS: http://www.zjnsf.gov.cn/h/01/news_view.aspx?appid=GUDD5EB45D5C95010591E580385CA982CF8).

26.   Lei Yu,* Yulan Wu, Hongen Cao, Xu Zhang, Xinkang Shi, Jie Luan, Tian Chen, Yi Pan, Qing Xu.* Facile Synthesis of 2-Methylenecyclobutanones via Ca(OH)₂-Catalyzed Direct Condensation of Cyclobutanone with Aldehydes and (PhSe)₂-Catalyzed Baeyer-Villiger Oxidation to 4-Methylenebutanolides. Green Chem. 2014, 16 (1), 287-293 (DOI:10.1039/C3GC41562G).

27.   Erlei Zhang, Haiwen Tian, Sendong Xu, XiaochunYu, Qing Xu.* Iron-Catalyzed Direct Synthesis of Imines from Amines or Alcohols and Amines via Aerobic Oxidative Reactions under Air. Org. Lett. 2013, 15 (11), 2704-2707 (DOI:10.1021/ol4010118, Highlighted by Organic Chemistry Portal: www.organic-chemistry.org/abstracts/lit4/049.shtm).

28.   Bo Huang, Haiwen Tian, Shoushuai Lin, Meihua Xie, Xiaochun Yu,* Qing Xu.* Cu(I)/TEMPO-Catalyzed Aerobic Oxidative Synthesis of Imines Directly from Primary and Secondary Amines under Ambient and Neat Conditions. Tetrahedron Lett. 2013, 54 (22), 2861-2864 (DOI:10.1016/j.tetlet.2013.03.098).

29.   Qing Xu,* Yong-Bo Zhou, Chang-Qiu Zhao, Shuang-Feng Yin, Li-Biao Han.^* Transition Metal-Catalyzed Efficient and Green Transformations of P(O)−H Compounds to Functional Organophosphorus Compounds. Mini-Rev. Med. Chem. 2013, 13 (6), 824-835 (DOI:10.2174/1389557511313060005).

30.   Qing Xu,* Jianhui Chen, Quan Liu. Aldehyde-Catalyzed Transition Metal-Free Dehydrative β-Alkylation of Methyl Carbinols with Alcohols. Adv. Synth. Catal. 2013, 355 (4), 697-704 (DOI:10.1002/adsc.201200996).

31.   Lei Yu,* Yulan Wu, Tian Chen, Yi Pan, Qing Xu.* Direct Synthesis of Methylene-1,2-dichalcogenolanes via Radical [3+2] Cycloaddition of Methylenecyclopropanes with Elemental Chalcogens. Org. Lett. 2013, 15 (1), 144-147 (DOI:10.1021/ol3031846).

32.   Qing Xu,* Qiang Li, Xiaogang Zhu, Jianhui Chen. Green and Scalable Aldehyde-Catalyzed Transition Metal-Free Dehydrative N-Alkylation of Amides and Amines with Alcohols. Adv. Synth. Catal. 2013, 355 (1), 73-80 (DOI:10.1002/adsc.201200881, Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2013/28October.shtm).

33.   Qing Xu,* Qiang Li. Recent Advances of Transition Metal-Catalyzed Aerobic Dehydrative Reactions of Alcohols and Amines and Related Reactions. Chin. J. Org. Chem. 2013, 33 (1), 18-35 (DOI:10.6023/cjoc201208016).

34.   Haiwen Tian, Xiaochun Yu, Qiang Li, Jianxin Wang, Qing Xu.* General, Green, and Scalable Synthesis of Imines from Alcohols and Amines by a Mild and Efficient Copper-Catalyzed Aerobic Oxidative Reaction in Open Air at Room Temperature. Adv. Synth. Catal. 2012, 354 (14-15), 2671-2677 (DOI:10.1002/adsc.201200574, Cited and commented by Science-2013-339-43 as an exceptionally good method for imine preparation from alcohols and amines)

35.   Qing Xu, Chang-Qiu Zhao, Yong-Bo Zhou, Shuang-Feng Yin, Li-Biao Han.* Transition Metal-Catalyzed Transformations of P(O)-H Bonds. Chin. J. Org. Chem. 2012, 32 (10), 1761-1775 (DOI:10.6023/cjoc201207024; Front Cover paper).

36.   Xiaochun Yu, Lan Jiang, Qiang Li, Yuanyuan Xie, Qing Xu.* Palladium-Catalyzed N-Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology. Chin. J. Chem. 2012, 30 (10), 2322-2332 (DOI:10.1002/cjoc.201200462; One of the most accessed papers from 8/2012 to 7/2013 published in Chin. J. Chem.; One of the most accessed papers in Top 25 from 5/2013 to 4/2014 published in Chin. J. Chem.)

37.   Qiang Li, Songjian Fan, Qing Sun, Haiwen Tian, Xiaochun Yu, Qing Xu.* Copper-Catalyzed N-Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology. Org. Biomol. Chem. 2012, 10 (15), 2966-2972 (DOI:10.1039/C1OB06743E; Front Cover paper; featured in the top 10% of the most highly cited articles published in the latest Impact Factor window 2011-2012).

38.   Shiheng Liao, Kangkang Yu, Qiang Li, Haiwen Tian, Zhengping Zhang, Xiaochun Yu, Qing Xu.* Copper-Catalyzed C-Alkylation of Secondary Alcohols and Methyl Ketones with Alcohols Employing the Aerobic Relay Race Methodology. Org. Biomol. Chem. 2012, 10 (15), 2973-2978 (DOI:10.1039/C1OB06739G; Front Cover paper; featured in the top 10% of the most highly cited articles published in the latest Impact Factor window 2011-2012).

39.   Xiaochun Yu, Chuanzhi Liu, Lan Jiang, Qing Xu.* Manganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air. Org. Lett. 2011, 13 (23), 6184-6187 (DOI:10.1021/ol202582c; Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/abstracts/lit3/476.shtm).

40.   Lan Jiang, Luolu Jin, Haiwen Tian, Xueqin Yuan, Xiaochun Yu,* Qing Xu.* Direct and Mild Palladium-Catalyzed Aerobic Oxidative Synthesis of Imines from Alcohols and Amines under Ambient Conditions. Chem. Commun. 2011, 47 (38), 10833-10835 (DOI:10.1039/c1cc14242a).

41.   Chuanzhi Liu, Shiheng Liao, Qiang Li, Sunlin Feng, Qing Sun, Xiaochun Yu,* Qing Xu.* Discovery and Mechanistic Studies of a General Air-Promoted Metal-Catalyzed Aerobic N-Alkylation Reaction of Amides and Amines with Alcohols. J. Org. Chem. 2011, 76 (14), 5759-5773 (DOI:10.1021/jo200862p).

42.   Sun Lin Feng, Chuan Zhi Liu, Qiang Li; Xiao Chun Yu, Qing Xu.* Rhodium-Catalyzed Aerobic N-Alkylation of Sulfonamides with Benzylic Alcohols. Chin. Chem. Lett. 2011, 22 (9), 1021-1024 (DOI:10.1016/j.cclet.2011.03.014; Rewarded by Chin. Chem. Lett. Editorial Office: Highly Cited Article (top 5%) Author Award of 2013).

43.   Chuanzhi Liu, Xufeng Zang, Baohua Yu, Xiaochun Yu,* Qing Xu.* Microwave-Promoted TBAF-Catalyzed S_NAr Reaction of Aryl Fluorides and ArSTMS: an Efficient Synthesis of Unsymmetrical Diaryl Thioethers. Synlett, 2011, (8), 1143-1148 (DOI:10.1055/s-0030-1259959).

44.   Qing Xu, Ruwei Shen, Yutaka Ono, Ritsuko Nagahata, Shigeru Shimada, Midori Goto, Li-Biao Han.* A New Oxapalladacycle Generated via Ortho C-H Activation of Phenylphosphinic Acid: Efficient Catalyst for Markovnikov-Type Additions of E-H Bonds to Alkynes. Chem. Commun. 2011, 47 (8), 2333-2335 (DOI:10.1039/c0cc03436c; Highlighted by Organic Chemistry Portal: www.organic-chemistry.org/Highlights/2011/31October.shtm; Highlighted by Labome: http://www.ncbi.nlm.nih.gov/pubmed/21161095).

45.   Qing Xu, Han, Li-Biao.* Metal-catalyzed additions of H-P(O) bonds to carbon-carbon unsaturated bonds. J. Organometallic Chem. 2011, 696 (1), 130-140 (DOI:10.1016/j.jorganchem.2010.08.043).

46.   Li-Biao Han,* Yutaka Ono, Qing Xu, Shigeru Shimada. Highly Selective Markovnikov-Type Addition of Hypervalent H-Spirophosphoranes to Alkynes Mediated by Palladium Acetate: Generality and Mechanism. Bull. Chem. Soc. Jpn. 2010, 83 (9), 1086-1099 (DOI:10.1246/bcsj.20100141).

47.   Gang Wang, Ruwei Shen, Qing Xu, Midori Goto, Yufen Zhao,* Li-Biao Han.* Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: a General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives. J. Org. Chem. 2010, 75 (11), 3890-3892 (DOI:10.1021/jo100473s).

48.   Qing Xu, Chang-Qiu Zhao, Li-Biao Han.* Stereospecific Nucleophilic Substitution of Optically Pure H-Phosphinates: A General Way for the Preparation of Chiral P-Stereogenic Phosphine Oxides. J. Am. Chem. Soc. 2008, 130 (38), 12648-12655 (DOI:10.1021/ja804412k).

49.   Qing Xu, Li-Biao Han.* Palladium-Catalyzed Asymmetric Hydrophosphorylation of Norbornenes. Org. Lett. 2006, 8 (10), 2099-2101 (DOI:10.1021/ol060568y).

50.   Qing Xu, Xian Huang,* Jingqi Yuan. Facile Synthesis of β-Organotellurobutenolides via Electrophilic Tellurolactonization of α-Allenoic Acids. J. Org. Chem. 2005, 70 (17), 6948-6951 (DOI:10.1021/jo050564r).

51.   Qing Xu, Xian Huang.* Cis-Carbocuperation of Acetylenic Sulfoxides and Corresponding Applications in the Regio- and Stereoselective Synthesis of Polysubstituted Vinyl Sulfoxides. Tetrahedron Lett. 2004, 45 (29), 5657-5660 (DOI:10.1016/j.tetlet.2004.05.141).

52.   Qing Xu, Xian Huang,* Jun Ni. Hydrotelluration and Carbotelluration of Acetylenic Sulfoxides: Regio- and Stereoselective Preparation of α- and β-Organotellurovinyl Sulfoxides. Tetrahedron Lett. 2004, 45(14), 2981-2984 (DOI:10.1016/j.tetlet.2004.02.064).

53.   Xian Huang,* Chun-Gen Liang, Qing Xu, Qi-Wen He. Alkyne-Based, Highly Stereo- and Regioselective Synthesis of Stereodefined Fucntionalized Vinyl Tellurides. J. Org. Chem. 2001, 66 (1), 74-80 (DOI:10.1021/jo001026b).